Leopard: Command-S not working in some apps!?

[Michael Grant]

OK, this is probably due to some semi-compatible hack I have
installed, and I haven't done any comprehensive testing yet, but I was
hoping someone here would recognize this. Since installing Leopard I'm
finding that typing command-s to save in some applications does
nothing and I have to save by either clicking a toolbar icon or
choosing from the File menu. I've noticed this in Excel 2004 and
BBEdit (this week's update, don't have the version number handy). I
also don't have keyboard access to menus through control-F2 in those
apps, although I do have it activated in the prefpane and it works
elsewhere. I haven't found any other keyboard commands that are
affected. Before I go through a laborious process of moving things
back and forth out of my Library and repeatedly logging in and out to
try to isolate a conflict (assuming it's not actually a bug in the OS,
which someone else would surely have noticed before now), does anyone
here have any idea what's going on?

TIA,
Michael

-- 
I never metadata I didn't like.